Saturday, December 8, 2018

Pathophysiology and Management of Type 2 Diabetes

Based on  The Author’s  US Provisional Patent  60/496, 397

Atef  M.  Elayyan
Amman   -   Jordan
atefesmail65@gmail.com
INTRODUCTION:
Type 2 diabetes is a long-term metabolic disorder that is characterized by high blood sugarinsulin resistance, and a relative lack of insulin.  This discovery is concerned with the relative lack of insulin.

Proposed Pathophysiology  of  Type 2 Diabetes:
When chromium chloride is proposed to partially release from voltage-gated calcium channels in pancreatic beta cells,  due to genetic vulnerability, obesity, oxidative stress, aging, eating habits, lifestyle and lack of exercise,  their threshold becomes low.  So the duration of their activation decreases, they will repolarize and inactivate on a current before rest potential current, i.e over - 70 mv.  So, voltage-gated calcium channels in pancreatic beta cells close faster than normal and calcium ions influx terminates thus, exocytosis process stops and insulin secretion terminates so,  secreted levels of insulin become lower than normal.  Thus, type 2  diabetes is predicted to develop.  As it is well known, there are grades of diabetes type 2,  when the release of chromium chloride is little diabetes type 2 is mild, on the other hand  when the release is high, diabetes becomes severe.   

CONCLUSION:
Based on our preliminary results – which are consistent with well established scientific literature - chromium supplements  serve as a long-term and  intermittent adjuvant approach that may lower glucose levels and retard the progression of type 2 diabetes. Via elevation of inactivation threshold of voltage-gated calcium channels in pancreatic beta cells thus, enhancing insulin secretion. Daily dose 200 mcg orally for a limited period of 12 weeks for adults along with standard treatment,  preferably under medical supervision.  Finally, we highly recommend intermittent  chromium supplementation   for type 2 diabetics and prediabetics.

























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*      This discovery does not endorse any product, it is for the sake of patients all over the world.


*       A daily dose of 1000 mcg of chromium compounds for six months or more may lead to   
           kidney failure.
 



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